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THCp cannabinoid

What is THCp (Tetrahydrocannabiphorol)?

Tetrahydrocannabiphorol (THCp) is a fairly new cannabinoid discovered by researchers at the UNIHEMP project in 2019. Unlike Delta-8 THC, THCp is incredibly strong at approximately 33 times more potency than THC.

Due to the increased potency, much smaller amounts of THCp would theoretically be needed to obtain effects similar to THC (Tetrahydrocannabinol).

THCp has not been widely studied in humans or animals and any consumption warrants caution. Any human THCp experiences reported in this article are purely anecdotal and do not endorse any use of THCp.

THCp is found in very small amounts in the cannabis plant, which could make it uneconomical to produce on a large scale.

THCp vs THC:

THCp vs THC
Reported EffectsTHCpDelta-9 THC
IncapacitatingYesYes
RelaxingYesYes
Helps with sleepNoYes
Causes DrowsinessNoYes
Causes AnxietyNoYes
Reduces AnxietyNoNo
Mood BoosterYesYes
Pain ReliefNoYes
Cotton MouthNoYes
Increased AppetiteUnknownYes
Reduces NauseaUnknownYes
*This list is a generalization, your experience may differ

How is Tetrahydrocannabiphorol (THCp) different from Tetrahydrocannabinol (THC)? Aside from the difference in potency, there is a difference in the chemical structure of THCp as well as different anecdotally reported effects.

Different Chemical Structure:

THCp differs chemically compared to THC because it has additional alkyl side chains – seven to be exact. That’s compared to THC which only has five alkyl side chains.

This difference is very simple chemically speaking, but the difference in potency is impressive. That’s because those extra two alkyl side chains make the THCp molecule bind to humans’ CB1 and CB2 cannabinoid receptors much more strongly compared to THC.

THCp Effects:

THCp has not yet been widely studied, so there is no definitive information about its effect on humans, except for some anecdotal reports found on the internet.

You can read some anecdotally reported effects below.

THCp Anecdotally Reported Effects on Humans:

THCp cannabinoid gummy

I decided to try gummy candies containing legal hemp derived THCp. These THCp gummies from WNC CBD are one of the first THCp products available – the THCp in these gummies is derived from legal hemp plants. Each gummy contains 0.3mg of THCp.

I started out very cautiously provided the novelty of this cannabinoid. One gummy is supposed to be equal to a 9 to 10mg THC edible.

Overall the effects were similar to THC except I didn’t experience the less desirable THC side effects such as increased appetite, drowsiness, or cotton mouth. Because of the lack of those undesirable side effects, I think THCp could potentially be better than THC if it were to ultimately prove safe for human consumption.

The duration of the effects was approximately 3 hours, but others have said it lasted longer for them.

3mg THC equivalent THCp dose:

At first I ate one third of one gummy – a small THC equivalent amount – about 3mg. No noticeable effects aside from being in a noticeably good mood for a couple hours.

4.5mg THC equivalent THCp dose:

On a different day I ate one half of one gummy. The effects were more pronounced. I experienced the same effects as THC, but without increased appetite, and no drowsiness at the tail end. I did experience increased heart rate, which is also common with THC consumption, for about 45 to 60 minutes.

6mg THC equivalent THCp dose:

On a third day I ate three quarters of one gummy. The effects were in-line with what I experienced when I previously ate one half gummy.

I have yet to consume an entire gummy, and I don’t expect a much different experience if I do. You can keep reading below for reports provided by other people who have eaten one or more of these same gummies.

I personally did not experience any negative side effects aside from the temporary increase in heart rate – but everyone reacts differently to THC (and THCp) and therefore you should also exercise extreme caution if you should decide to consume a THCp product.

9mg and above THC equivalent dose:

Other people have reported their experiences consuming one fully gummy or more, which is equivalent to 9mg of THC or more. Here are some of their reported experiences:

One person with a very high THC tolerance reported eating 5 of gummies at once, which is equivalent to about 45mg to 50mg of THC. The only mentioned side effect was a “crazy crazy high” appetite.

Another person gave a more detailed account and reported “feeling body effects,” “elevated taste,” and that the effects came in waves. This person also used other cannabinoids later during their experience.

A third person reported their experience as “It’s hard to explain tbh. I feel numb at my lips and extremities and there is a sort of pressure in my head but it’s all very gentle feeling if that makes sense. I’m getting a nice relaxing feeling as well.

The main difference for me is D9 is very edgy on the come up for me whereas this is subtler and gentler”

Is THCp Dangerous?

You should always be cautious in your use of THCp products. But for the sake of discussion I’ll look at the THCp dosages and side effects given to mice in the study performed by the scientists who discovered THCp.

Any effects observed on mice won’t necessarily carry over to humans, which is why the US FDA does not approve drugs based solely on mice studies. But let’s see how much THCp was given to mice and how they reacted:

The tetrad includes the assessment of spontaneous activity, immobility index (catalepsy), analgesia and changes in rectal temperature. Decrease of locomotor activity, catalepsy, analgesia and hypothermia are well-known signs of physiological manifestations of cannabinoid activity40. After intraperitoneal (i.p.) administration, Δ9-THCP at 2.5 mg/kg markedly reduced the spontaneous activity of mice in the open field, while at 5 and 10 mg/kg it induced catalepsy on the ring with the immobility as compared to the vehicle treated mice (Fig. 4b,c) (0 mg/kg: 6888 cm ± 474.8, 10 mg/kg: 166.8 cm ± 20.50, 5 mg/kg: 127.5 cm ± 31.32, 2.5 mg/kg: 4072 cm ± 350.8, p = 0.0009).

First, I’d like to put this excerpt from the THCp study into context.

It says the mice experienced markedly reduced spontaneous activity while roaming an open field, and catalepsy at doses of 5 and 10mg/kg of body weight.

Catalepsy is definitely not a side effect to ignore, whether on mice or humans.

With that said – it’s also important to put the absurdly high dose of THCp given to the mice in context. The mice were given doses of 5mg per kg of body weight, and 10mg per kg of body weight.

A 5mg per kg dose is the equivalent of giving a 140 pound human 317.5mg of THCp, which is 33x stronger than THC. So 5mg per kg on a 140 pound human would be a THC equivalent dose of 10,477mg of THC. Now you know why the mice experienced catalepsy! I don’t think any human has ever consumed 5% of that number at one time!

Even the lowest dose in the study of 2.5mg per kg is absurdly high! I don’t know if this was intentional or if the scientists didn’t understand what the equivalent THC dose would work out to.

I think a good conclusion regarding this early THCp study is to be cautious, but also read between the lines. Want to read through the full study? It’s available free here.

In my video review below you’ll see I started with a small one third gummy to ensure there were no negative side effects.

THCp Video Review:

THCp Review - New Hemp Derived Cannabinoid! - Better than THC???
Due to age restriction, you need to log in to YouTube to view my video review of THCp.

Conclusion

Overall there are still very few reports about this new cannabinoid’s effects on humans. If (big if) it does prove similar to THC without any serious side effects, then it could potentially act as a good THC alternative for people in areas where hemp is legal but THC is illegal.

Like reading about cannabinoids? Check out my posts about CBG and CBD, and How to make homemade oil from flower or isolate!

References:

What is THCp?

THCp is a recently discovered cannabinoid that’s up to 33 times more potent than THC. THCp is naturally occurring in small amounts in cannabis plants, and contains two extra carbon alkyl side chains (total of seven) compared to THC.